Key Publications

• Nguyen DD*, Yu WJ*, Barulin A+,  Park JC+, Kim I+. Coincident Fluorescence-Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles from Human Induced Pluripotent Stem Cells. Adv Sci. (Weinh). 2025 Dec 29:e14421. doi: 10.1002/advs.202514421. (IF = 15.1)  
• Jo Y*, Kim Y*, Kang R*, Park JC+, Kim I+. Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno-SERS. Adv Sci (Weinh). 2025 May 30:e05660. doi: 10.1002/advs.202505660. (IF = 15.1)
• Barulin A*, Barulina E*, Oh DK*, Park H, Park S, Jo Y, Kim J, Bhak GS, Kim Y, Kang H, Park Y, Park JC+, Rho J+, Park B+, Kim I+. Axially multifocal metalens for 3D volumetric photoacoustic imaging of neuromelanin in live brain organoid. Sci. Adv. 2025 Jan 17;11(3):eadr0654. doi: 10.1126/sciadv.adr0654. (IF = 11.7)  [유스라인][대학저널]
  
• Park JC*, Han J*, Lee W, Kim J, Lee SE, Lee D, Choi H, Han J, Kim JI, Mook-Jung I+. Microglia gravitate toward the amyloid plaques surrounded by externalized phosphatidylserine via TREM2. Adv Sci (Weinh). 2024 Sep;11(34):e2400064. doi: 10.1002/advs.202400064. (IF = 17.521) [동아사이언스][의협신문][의학신문][메디컬투데이][메디파나뉴스][코리아헬스로그][아이뉴스24][브레인미디어][코메디닷컴][한국강사신문]
• Park JC*, Lim H, Byun MS, Yi D, Byeon G, Jung G, Kim YK, Lee DY, Han SH+, Mook-Jung I+. Sex differences in the progression of glucose metabolism dysfunction in Alzheimer's disease. Exp Mol Med. 2023 May;55(5):1023-1032. doi: 10.1038/s12276-023-00993-3. (IF= 12.800) 
• Park JC*, Barahona-Torres N*, Jang SY*, Mok KY, Kim HJ, Han SH, Cho KH, Zhou X, Fu AKY, Ip NY, Seo J, Choi M, Jeong H, Hwang D, Lee DY, Byun MS, Yi D, Han JW, Mook-Jung I+, Hardy J+. Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology. Adv Sci (Weinh). 2022 Jun 13:e2201212. doi: 10.1002/advs.202201212. (IF = 17.521) [연합뉴스] [메디컬투데이] [데일리메디][뉴시스]
• Park JC*, Jang SY*, Lee D*, Lee J, Kang U, Chang H, Kim HJ, Han SH, Seo J, Choi M, Lee DY, Byun MS, Yi D, Cho KH+, Mook-Jung I+. A logical network-based drug-screening platform for Alzheimer's disease representing pathological features of human brain organoids. Nat. Commun. 2021 Jan 12;12(1):280. doi: 10.1038/s41467-020-20440-5. (IF = 17.694) [이투데이] [메디칼업저버] [한겨례]
• Park JC*, Han SH, Lee H, Jeong H, Byun M, Bae J, Kim H, Lee DY, Hwang D, Lee SW, Mook-Jung I+. Prognostic plasma protein panel for brain Abeta deposition in Alzheimer’s disease. Prog Neurobiol. 2019 Dec:101690. doi: 10.1016/j.pneurobio.2019.101690. (IF = 10.885) [정부정책브리핑][한국대학신문]
• Park JC*, Han SH*, Yi D*, Byun MS, Lee JH, Jang S, Ko K, Jeon SY, Lee YS, Kim YK, Lee DY, Mook-Jung I. Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimers disease. Brain. 2019 May 1;142(5):e19. doi: 10.1093/brain/awz033. (IF = 15.255) [아주경제] [동아사이언스] [정부정책브리핑] [동아일보]
• Park JC*, Baik SH, Han SH, Cho HJ, Choi H, Kim HJ, Cho H, Lee W, Kim DK, Mook-Jung I+. Annexin A1 restores Aβ1-42- induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway. Aging Cell. 2017 Feb;16(1):149-161. doi: 10.1111/acel.12530. (IF = 11.005) 

Full-List

2026

• Kim S*, S. Kumar*, G. Na*, M. Lee, W. Yu, D.P. Kim+,  Park JC+. Dual prodrug lipid nanoparticles enhance neuronal activation and pathology reduction in Alzheimer’s Disease models using brain organoids. Nat. Chem. Biol. (Under review, IF = 13.7)
• Kim S, W. Yu, M. Lee, R. Kang, G. Bak, L.P. Lee,  Park JC+, TREM2-mutant intestinal exosomes induce AD-like pathology in brain organoids. Nat. Commun. (In submission, IF=15.7)
• H. Truong*, S. Shin*, T. Hoang, L. Zha, B. Park, I. Kim, L.P. Lee+, Park JC+ . Ageing control of brain organoid generation by nanoplasmonic optical antennas. Nat. aging. (In submission, IF = 17.0)
• Yoo J*, Lee T*, Park H, Kim S, Luke P. Lee+,Park B+, Park JC+. Sono-epigenetics: A Non-invasive Method for Gene Expression Control. Nat. Commun. (In submission, IF=14.7)
• Yoo J*, Kim Y*, Yu WJ*, Kim S, Park JC+, Kim I+,Park B+. Ultrasound-Amplified Exosome Secretion and Antibody-Free SERS Profilingfor Alzheimer’s Disease Signatures via iPSC-Derived Cortical Organoids. Sci. Adv. (Under revision, IF = 11.7)
• Lee T*, Luke P. Lee+, Park JC+ , Biocompatible Graphene Quantum Dots For Personalized Precision Medicine : Neurological Applications in Brain Organoids. BMEF. (in submission, IF = 5.0)
• H. Cho*, Y. Kim*, N. Yoon*, T. Hoang*, J. Ahn, Park JC+, I. Kim+. Nanoplasmonic aptasensing enables real-time optical monitoring of neurotransmitters in living brainstem organoids. Nat. Commun. (Under review, IF = 15.7)
• Shin S*, Zhu X*, Amartumur S, Lee T, Yu WJ, Park S, Etemadi N, Jamsranjav A, Kang R, Bak G, Lee SE+, Park JC+ . Human brain and organoid transcriptomes reveal key receptor tyrosine kinase pathways and genetic signatures in Alzheimer’s disease. EMM. (Accepted, IF = 12.9)

2025

• Nguyen DD*, Yu WJ*, Barulin A+,  Park JC+, Kim I+. Coincident Fluorescence-Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles from Human Induced Pluripotent Stem Cells. Adv Sci. (Weinh). 2025 Dec 29:e14421. doi: 10.1002/advs.202514421. (IF = 15.1)  
• Yongjae Jo* , Hanjun Cho* , Jungah Kim* , Yangkyu Kim* , Saewoon Shin, Park JC+ and Inki Kim+. Metalens for passive generation of a droplet Bessel beam. Microsystems & Nanoengineering. 2025 Nov 24;11(1):224. doi: 10.1038/s41378-025-01106-y. PMID: 41285718. (Accepted, IF = 9.9 )
• Min-Ji Kang, Yeon-Woo Cho, Joon-Ha Park, Yun-Sik Eom, Seongmin Kim, Taehoon Lee, Park JC, Zhengtang Luo, Jin-Ha Choi, Tae-Hyung Kim. Graphene Oxide-Wrapped Hierarchical Gold Nanopillar Hybrids for Real-Time, Non-Destructive Dopamine Sensing in Neurons and Midbrain Organoids. Adv. Funct. Mater.  (IF = 19.0) 
• Yei J, Lee NK, Ryu S, Ryu SE, Lee J, Park T, Jeong Y, Kang R, Kwon HK, Kim SG, Park JC, Park CG, Suh M. Glioma-Associated Microglia Potentiate Neuronal Hyper-Excitability in the Glioma Environment. Neuro Oncol. 2025 Jul 30:noaf181. doi: 10.1093/neuonc/noaf181. (IF = 13.4)  
• Byun MJ, Nakasone ES, Shin HE, Lee H, Park JC, Lee W, Park W, Park CG, Park J, Kim SN. Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases. Adv Healthc Mater. 2025 Jul 22:e2502092. doi: 10.1002/adhm.202502092. (IF = 9.6) 
• Jo Y*, Kim Y*, Kang R*, Park JC+, Kim I+. Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno-SERS. Adv Sci (Weinh). 2025 May 30:e05660. doi: 10.1002/advs.202505660. (IF = 15.1)
• Barulin A*, Barulina E*, Oh DK*, Park H, Park S, Jo Y, Kim J, Bhak GS, Kim Y, Kang H, Park Y, Park JC+, Rho J+, Park B+, Kim I+. Axially multifocal metalens for 3D volumetric photoacoustic imaging of neuromelanin in live brain organoid. Sci. Adv. 2025 Jan 17;11(3):eadr0654. doi: 10.1126/sciadv.adr0654. (IF = 11.7)  [유스라인][대학저널]
• Kim BS*, Hwang I*, Ko HR, Kim YK, Kim HJ, Seo SW, Choi Y, Lim S, Kim YK, Nie S, Ye K, Park JC, Lee Y, Jo DG, Lee SE, Kim D, Cho SW, Ahn JY. EBP1 potentiates Amyloid β pathology by regulating PSEN/γ -secretase. Nat. Aging. 2025 Jan 8. doi: 10.1038/s43587-024-00790-1. (IF = 17.0) 
• Yongjae Jo, Hyemi Park, Seho Lee, Hyeyoung Yoon, Taehoon Lee, Gyu Soo Bak, Park JC+ , Inki Kim. Metasurface-based super-resolution image scanning microscopy(Conference Presentation) Quantum Effects and Measurement Techniques in Biology and Biophotonics II.2025 March 21:Proc. SPIE 13340.133400D
• Byullee Park, Aleksandr Barulin, Elena Barulina, Dong Kyo Oh, Soomin Park, Hyunjun Kye, Jeesu Kim, Park JC+  , Junsuk Rho, Inki Kim. Neuromelanin imaging of brain organoids using metalens-based photoacoustic microscopy with extended depth-of-field (Conference Presentation). Photons Plus Ultrasound: Imaging and Sensin. 2025 March 20:Proc. SPIE 13319, 133190T

2024

• Kwak T*, Park SH*, Lee S, Shin Y, Yoon KJ, Cho SW, Park JC+, Yang SH, Cho H, Im HI, Ahn SJ, Sun W, Yang JH. Guidelines for Manufactureing and Application of Organoids: Brain. Int J Stem Cells. 2024 May 30;17(2):158-181. doi: 10.15283/ijsc24056. (IF = 2.5) 
• Chung S*, Jeong J*, Park JC, Han JW, Lee Y, Kim JI+, Mook-Jung I+. Blockade of STING activation alleviates microglial dysfunction and a broad spectrum of Alzheimer's disease pathologies. Exp Mol Med. 2024 Sep;56(9):1936-1951. doi: 10.1038/s12276-024-01295-y. (IF = 9.5)
• Lee SE*, Park S*, Kang R, Lee T, Yu WJ, Chang S, Park JC+. Hippocampal tau-induced GRIN3A deficiency in Alzheimer's disease. FEBS Open Bio. 2024 Dec;14(12):2059-2071. doi: 10.1002/2211-5463.13904. (IF = 3.0) 
• Park JC*, Han J*, Lee W, Kim J, Lee SE, Lee D, Choi H, Han J, Kim JI, Mook-Jung I+. Microglia gravitate toward the amyloid plaques surrounded by externalized phosphatidylserine via TREM2. Adv Sci (Weinh). 2024 Sep;11(34):e2400064. doi: 10.1002/advs.202400064. (IF = 17.521) [동아사이언스][의협신문][의학신문][메디컬투데이][메디파나뉴스][코리아헬스로그][아이뉴스24][브레인미디어][코메디닷컴][한국강사신문]
• Kang R*, Park S*, Shin S*, Bak G, Park JC+ . Electrophysiological insights with brain organoid models: a brief review. BMB Rep. 2024 Jul;57(7):311-317. doi: 10.5483/BMBRep.2024-0077.  (IF = 2.9) 
• Park S, Park JC+, Advancements in brain organoid models for neurodegenerative disease research, Organoid. (IF = coming soon) 
• Zha L*, Shin S*, Kim C, Park JC+, Park B+. 3D bioprinting and label-free imaging: bridging innovations for organoid research. Int J Bioprint. 2024 Dec;10(1):5732. doi:10.36922/ijb.5732.  (IF = 6.8).  
• Na H*, Shin KY*, Lee D, Yoon C, Han SH, Park JC, Mook-Jung I, Jang J, Kwon S. Improvement of clinical diagnosis accuracy of Alzheimer's disease using multiple blood biomarkers. Laboratory Medicine Online. 2024 Oct;14(4):330-338. doi:10.47429/lmo.2024.14.4.330. 

2023

• Park JC*, Lim H, Byun MS, Yi D, Byeon G, Jung G, Kim YK, Lee DY, Han SH+, Mook-Jung I+. Sex differences in the progression of glucose metabolism dysfunction in Alzheimer's disease. Exp Mol Med. 2023 May;55(5):1023-1032. doi: 10.1038/s12276-023-00993-3. (IF= 12.800)
• Na H, Shin KY, Lee D, Yoon C, Han SH, Park JC, Mook-Jung I+, Jang J, Kwon S. The QPLEX™ Plus Assay Kit for the Early Clinical Diagnosis of Alzheimer's Disease. Int J Mol Sci. 2023 Jul 5;24(13):11119. doi: 10.3390/ijms241311119. (IF= 4.9) 

 2022

• Park JC, Mook-Jung I. Toward brain organoid-based precision medicine in neurodegenerative diseases. Organoid. 2022;2:e21. https://doi.org/10.51335/organoid.2022.2.e21 (IF = coming soon)
• Park JC, Noh J, Jang S, Kim KH, Choi H, Lee D, Kim J, Chung J, Lee DY, Lee Y, Lee H, Yoo DK, Lee AC, Byun MS, Yi D, Han SH, Kwon S, Mook-Jung I. Association of B cell profile and receptor repertoire with the progression of Alzheimer's disease. Cell Rep. 2022 Sep 20;40(12):111391. (IF = 9.995)  [메디컬투데이] [청년의사]
• Park JC*, Barahona-Torres N*, Jang SY*, Mok KY, Kim HJ, Han SH, Cho KH, Zhou X, Fu AKY, Ip NY, Seo J, Choi M, Jeong H, Hwang D, Lee DY, Byun MS, Yi D, Han JW, Mook-Jung I+, Hardy J+. Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology. Adv Sci (Weinh). 2022 Jun 13:e2201212. doi: 10.1002/advs.202201212. (IF = 17.521) [연합뉴스] [메디컬투데이] [데일리메디][뉴시스]
• Kim J, Lee S, Lee J, Park JC, Kim KH, Ko JM, Park SH, Kim SK, Mook-Jung I, Lee JY. Neurotoxicity of phenylalanine on human iPSC-derived cerebral organoids. Mol Genet Metab. 2022 Jun;136(2):132-144. doi: 10.1016/j.ymgme.2022.04.005. (IF = 4.204) 
• Lee D*, Park JC*, Jung KS, Kim J, Jang JS, Kwon S, Byun MS, Yi D, Byeon G, Jung G, Kim YK, Lee DY, Han SH, Mook-Jung I. Application of QPLEXTM biomarkers in cognitively normal individuals across a broad age range and diverse regions with cerebral amyloid deposition. Exp Mol Med. 2022 Jan;54(1):61-71. doi: 10.1038/s12276-021-00719-3. (IF = 12.172) 

2021

• Kim HJ*, Park JC*, Jung KS*, Kim J, Jang JS, Kwon S, Byun MS, Yi D, Byeon G, Jung G, Kim YK, Lee DY, Han SH, Mook-Jung I+. The clinical use of blood-test factors for Alzheimer's disease: improving the prediction of cerebral amyloid deposition by the QPLEXTM Alz plus assay kit. Exp Mol Med.  2021 Jun 9. doi: 10.1038/s12276-021-00638-3. (IF = 12.172) 
• Park JC*, Jang SY*, Lee D*, Lee J, Kang U, Chang H, Kim HJ, Han SH, Seo J, Choi M, Lee DY, Byun MS, Yi D, Cho KH+, Mook-Jung I+. A logical network-based drug-screening platform for Alzheimer's disease representing pathological features of human brain organoids. Nat. Commun. 2021 Jan 12;12(1):280. doi: 10.1038/s41467-020-20440-5. (IF = 17.694) [이투데이] [메디칼업저버] [한겨례]
• Park JC, Jung KS, Kim J, Jang JS, Kwon S, Byun MS, Yi D, Byeon G, Jung G, Kim YK, Lee DY, Han SH, Mook-Jung I. Performance of the QPLEX Alz plus assay, a novel multiplex kit for screening cerebral amyloid deposition. Alzheimers Res Ther. 2021 Jan 6; 13(1):12. (IF = 8.831) 

2020

• Seo J, Byun MS, Yi D, Lee JH, Jeon SY, Shin SA, Kim YK, Kang KM, Sohn CH, Jung G, Park JC, Han SH, Byun J, Mook-Jung I, Lee DY, Choi M; KBASE Research Group. Genetic associations of in vivo pathology influence Alzheimer’s disease susceptibility. Alzheimers Res Ther. 2020 Nov 19;12(1);156. (IF = 8.831) 
• Yun Y, Lee SY, Choi WH, Park JC, Lee DH, Kim YK, Lee JH, Lee JY, Lee MJ, Kim YH. Proteasome activity in the plasma as a novel biomarker in mild cognitive impairment with Chronic Tinnitus. J Alzheimers Dis.  2020;78(1):195-205. (IF = 4.160) 
• Park JC, Han SH, Mook-Jung I. Peripheral inflammatory biomarkers in Alzheimer’s Disease: A brief review. BMB Rep. 2020 Jan; 53 (1), 10-19. (IF = 5.041) 
• Choi H, Kim H, Yang J, Chae S, Lee W, Chung S, Kim J, Choi H, Song H, Lee CK, Jun JH, Lee YJ, Lee K, Kim S, Sim H, Choi Y, Ryu KH, Park JC, Lee D, Han SH, Hwang D, Kyung J, Mook-Jung I. Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models. Aging Cell. 2020 Jan 19; (1), e13081. (IF = 11.005) 

2019

• Kim DK, Han D, Park J, Choi H, Park JC, Cha MY, Woo J, Byun MS, Lee DY, Kim Y, Mook-Jung I. Deep proteome profiling of hippocampus in 5XFAD Mouse model uncovers biological process alterations and a novel biomarker of Alzheimer’s disease. Exp Mol Med. 2019 Nov 15; 51 (11), 136. (IF = 12.172) 
• Park JC*, Han SH, Lee H, Jeong H, Byun M, Bae J, Kim H, Lee DY, Hwang D, Lee SW, Mook-Jung I+. Prognostic plasma protein panel for brain Abeta deposition in Alzheimer’s disease. Prog Neurobiol. 2019 Dec:101690. doi: 10.1016/j.pneurobio.2019.101690. (IF = 10.885) [정부정책브리핑][한국대학신문]
• Park JC*, Han SH*, Yi D*, Byun MS, Lee JH, Jang S, Ko K, Jeon SY, Lee YS, Kim YK, Lee DY, Mook-Jung I. Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimers disease. Brain. 2019 May 1;142(5):e19. doi: 10.1093/brain/awz033. (IF = 15.255) [아주경제] [동아사이언스] [정부정책브리핑] [동아일보]
• Han SH*, Park JC*, Byun MS, Yi D, Lee JH, Lee DY, Mook-Jung I+. Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals. Neurobiol Aging. 2019 Jan;73:21-29. (IF = 5.133) 

2017

• Park JC, Han SH, Byun MS, Yi D, Lee JH, Park K, Lee DY, Mook-Jung I+. Low Serum Phosphorus Correlates with Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results from the KBASE Study. Front Aging Neurosci. 2017 Nov 6;9:362. (IF = 5.702) 
• Park JC, Han SH, Cho HJ, Byun MS, Yi D, Choe YM, Kang S, Jung ES, Won SJ, Kim EH, Kim YK, Lee DY, Mook-Jung I. Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition. Alzheimers Res Ther. 2017 Mar 22;9(1):20. (IF = 8.831) 
• Park JC*, Baik SH, Han SH, Cho HJ, Choi H, Kim HJ, Cho H, Lee W, Kim DK, Mook-Jung I+. Annexin A1 restores Aβ1-42- induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway. Aging Cell. 2017 Feb;16(1):149-161. doi: 10.1111/acel.12530. (IF = 11.005)

2016

• Han SH, Park JC, Mook-Jung I. Amyloid β-interacting partners in Alzheimer’s disease: From accomplices to possible therapeutic targets. Prog Neurobiol. 2016 Feb;137:17-38. (IF = 10.885) 

2015

• Han SH, Park JC, Mook-Jung I+. Biomarkers in Alzheimer’s Disease: From Pathogenic Initiation to Downstream Outcomes. In book: Aging Mechanisms. 2015 Jan; 341-354. (IF = n/a)

2014

• Park R, Kook SY, Park JC, Mook-Jung I+. Aβ1-42 reduces P-glycoprotein in the blood-brain barrier through RAGE-NK-kB signaling. Cell Death Dis. 2014 Jun 26;5:e1299. (IF = 9.696)